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Hunter Guevara LR, Beam WBB, Pasternak JJ (2024) To the Brain and Beyond: Neurological Implications of Glucagon-Like Peptide-1 Receptor Agonists

The exact reason 3-MCC remains benign for most patients is not fully understood, but the body often finds alternative metabolic pathways to manage the protein safely without causing toxic buildups [7] [2]

However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort